Peptide Information

General Information of This Peptide
Peptide ID
BTDP005895
Peptide Name
Exenatide
Symonym
Byetta; Exenatide; Exendin-4; 141758-74-9; Bydureon; Exendin 4 (Heloderma suspectum); AC2993A; AC 2993; AC002993; GTPL1135; SCHEMBL20509814; AKOS034831545; NS00040800;Exendin-4
Species
Heloderma suspectum (Gila monster)
Uniprot Name
EXE4_HELSU
Alphafold ID
P26349
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1JRJ
Sequence
MKIILWLCVFGLFLATLFPISWQMPVESGLSSEDSASSESFASKIKRHGEGTFTSDLSKQ
MEEEAVRLFIEWLKNGGPSSGAPPPSG
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Sequence Length
87
Mass (Da)
9479
Sequence Removed Signal Peptide
MKIILWLCVFGLFLATLFPISWQMPVESGLSSEDSASSESFASKIKRHGEGTFTSDLSKQ
MEEEAVRLFIEWLKNGGPSSGAPPPSG
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PDB ID
1JRJ , 2MJ9 , 2NAV , 2NAW , 3C59 , 3C5T , 5NIQ , 5OTT , 6GDZ , 6GE2 , 7LLL , 7MLL
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Helodermatidae
Genus: Heloderma
Species: Heloderma suspectum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    GLP-1 receptor Dissociation constant
0.5 nM
 . . [1]
References
Ref 1 Thorens, Bernard, et al. "Cloning and functional expression of the human islet GLP-1 receptor: demonstration that exendin-4 is an agonist and exendin-(939) an antagonist of the receptor." Diabetes 42.11 (1993): 1678-1682.
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