Peptide Information

General Information of This Peptide
Peptide ID
BTDP005698
Peptide Name
Alpha-conotoxin LvIC
Species
Conus lividus (Livid cone)
Uniprot Name
CA1C_CONLI
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
SNGRNAAAGDKPSYWITLAITDCCANPVCNGKHCQGRR
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Sequence Length
38
Mass (Da)
4050
Sequence Removed Signal Peptide
SNGRNAAAGDKPSYWITLAITDCCANPVCNGKHCQGRR
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Disulfide Bond
23-29;24-34
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus lividus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
3.3 μM
 . . [1]
References
Ref 1 Discovery, Characterization, and Engineering of LvIC, an 4/4-Conotoxin That Selectively Blocks Rat 6/34 Nicotinic Acetylcholine Receptors. J Med Chem. 2023 Feb 9;66(3):2020-2031. doi: 10.1021/acs.jmedchem.2c01786. Epub 2023 Jan 22.
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