Peptide Information

General Information of This Peptide
Peptide ID
BTDP005652
Peptide Name
PI-stichotoxin-Hcr2o
Symonym
GS-polypeptide 1; Kunitz-type serine protease inhibitor HCGS1.20
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
VKT2O_HETCR
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
GSICLEPKVVGPCTAYFPRFYFDSETGKCTPEIYGGCEGNSYDEKLHACRAICRA
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Mutant Sequence
GSICLEPKVVGPCKARIRRFYFDSETGKCTPFIYGGCGGNGNNFETLHACRAICRA
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Sequence Length
56
Mass(Da)
6086
Sequence Removed Signal Peptide
GSICLEPKVVGPCKARIRRFYFDSETGKCTPFIYGGCGGNGNNFETLHACRAICRA
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Disulfide Bond
4-54;13-37;29-50
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
21 nM
 . . [1], [2], [3]
 Target Info    chymotrypsin Inhibition constant
500 nM
 . . [1], [2], [3]
References
Ref 1 A new multigene superfamily of Kunitz-type protease inhibitors from sea anemone Heteractis crispa. Peptides. 2012 Mar;34(1):88-97. doi: 10.1016/j.peptides.2011.09.022. Epub 2011 Oct 5.
Ref 2 Analgesic effect of novel Kunitz-type polypeptides of the sea anemone Heteractis crispa. Dokl Biochem Biophys. 2015;461:80-3. doi: 10.1134/S1607672915020052. Epub 2015 May 5.
Ref 3 Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model. Biomedicines. 2021 Mar 10;9(3):283. doi: 10.3390/biomedicines9030283.
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