Peptide Information

General Information of This Peptide
Peptide ID
BTDP005502
Peptide Name
OMEGA-myrmeciitoxin(02)-Mg1a
Symonym
MIITX2-Mg1a; OMEGA-MIITX(02)-Mg1a
Species
Myrmecia gulosa (Red bulldog ant)
Uniprot Name
TX21A_MYRGU
Alphafold ID
P0DSL4
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 7R6P
Sequence
MKNNYISTCIVYLMAALLLISVISIKECTADISDYGDPCSDDLKDYCIHGDCFFLKELNQ
PACRCYTGYYGSRCEHIDHN
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Sequence Length
80
Mass (Da)
9099
Signal Sequence
MKNNYISTCIVYLMAALLLISVISIKECTA
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Sequence Removed Signal Peptide
DISDYGDPCSDDLKDYCIHGDCFFLKELNQPACRCYTGYYGSRCEHIDHN
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Disulfide Bond
39-52;47-63;65-74
PDB ID
7R6P
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Hymenoptera
Family: Formicidae
Genus: Myrmecia
Species: Myrmecia gulosa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    EGFR Effective concentration 50
6.3 nM
 . . [1], [2]
References
Ref 1 A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family. Sci Adv. 2018 Sep 12;4(9):eaau4640. doi: 10.1126/sciadv.aau4640. eCollection 2018 Sep.
Ref 2 A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2112630119. doi: 10.1073/pnas.2112630119.
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