Peptide Information

General Information of This Peptide
Peptide ID
BTDP005446
Peptide Name
NU-conotoxin-Ltg1a
Symonym
N-CTX-Ltg1a
Species
Conus litoglyphus (Lithograph cone)
Uniprot Name
CU1A_CONLO
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
LFHYCQCQCPPGFKGKFCQFKLRPP
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Sequence Length
25
Mass (Da)
2974
Sequence Removed Signal Peptide
LFHYCQCQCPPGFKGKFCQFKLRPP
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus litoglyphus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    melanocortin subtype MC3R Affinity
˜100 nM
 . . [1]
 Target Info    melanocortin subtype MC4R Affinity
˜50 nM
 . . [1]
 Target Info    melanocortin subtype MC5R Affinity
˜50 nM
 . . [1]
 Target Info    melanocortin subtype MC1R Affinity
˜500 nM
 . . [1]
 Target Info    melanocortin subtype MC4R Affinity
15 nM
 . . [1]
 Target Info    melanocortin subtype MC3R Affinity
40 nM
 . . [1]
 Target Info    melanocortin subtype MC5R Affinity
200 nM
 . . [1]
 Target Info    melanocortin subtype MC1R Affinity
200 nM
 . . [1]
References
Ref 1 From a Cone Snail Toxin to a Competitive MC4R Antagonist. J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5.
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