General Information of This Peptide
Peptide ID
BTDP005442
Peptide Name
Turritoxin F21-2
Symonym
Turripeptide F21-2
Species
Polystira nobilis (Sea snail) (Pleurotoma nobilis)
Uniprot Name
TUL2_POLNO
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
WFRSFKSYYGHHGSVYRPNEPNFRSFAS
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Sequence Length
28
Mass (Da)
3425
Sequence Removed Signal Peptide
WFRSFKSYYGHHGSVYRPNEPNFRSFAS
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Turridae
Genus: Polystira
Species: Polystira nobilis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7 Inhibition rate
55 %
5.6 μM
. [1]
 Target Info    nAChR alpha-3-beta-2 IC50
566.2 nM
. . [1]
References
Ref 1 A turripeptide from Polystira nobilis venom inhibits human 32 and 7 nicotinic acetylcholine receptors. Insect Biochem Mol Biol. 2020 Sep;124:103416. doi: 10.1016/j.ibmb.2020.103416. Epub 2020 Jun 24.
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