Peptide Information

General Information of This Peptide
Peptide ID
BTDP005389
Peptide Name
Alpha-conotoxin CIC
Symonym
C1.1; Ca001
Species
Conus catus (Cat cone)
Uniprot Name
CA1C_CONCT
Alphafold ID
P0DQQ5
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQQ5
Sequence
ASGADTCCSNPACQVQHSDLC
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Sequence Length
21
Mass (Da)
2110
Sequence Removed Signal Peptide
ASGADTCCSNPACQVQHSDLC
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Disulfide Bond
7-13;8-21
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus catus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
0.94 μM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
3.51 μM
 . . [1], [2]
References
Ref 1 Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. J Proteome Res. 2015 Oct 2;14(10):4372-81. doi: 10.1021/acs.jproteome.5b00630. Epub 2015 Sep 10.
Ref 2 Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel -Conotoxin with an Extended N-Terminal Tail. Mar Drugs. 2021 Mar 2;19(3):141. doi: 10.3390/md19030141.
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