Peptide Information

General Information of This Peptide
Peptide ID
BTDP005363
Peptide Name
Conotoxin Czon1107
Species
Conus zonatus (Zoned cone)
Uniprot Name
CX07_CONZO
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6KN2
Sequence
GFRSPCPPFC
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Sequence Length
10
Mass (Da)
1110
Sequence Removed Signal Peptide
GFRSPCPPFC
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Disulfide Bond
610
PDB ID
6KN2
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus zonatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-4 IC50
15.7 nM
 . . [1], [2]
 Target Info    nAChR alpha-7 IC50
77.2 nM
 . . [1], [2]
References
Ref 1 Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human 34 and 7 nicotinic acetylcholine receptors. J Biol Chem. 2020 May 15;295(20):7096-7112. doi: 10.1074/jbc.RA119.012098. Epub 2020 Mar 31.
Ref 2 Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human 34 Nicotinic Acetylcholine Receptor. Mar Drugs. 2022 Jul 31;20(8):497. doi: 10.3390/md20080497.
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