Peptide Information

General Information of This Peptide
Peptide ID
BTDP005344
Peptide Name
Exactin
Symonym
Extrinsic tenase-mediated FX activation inhibitor
Species
Hemachatus haemachatus (Rinkhals) (Sepedon haemachatus)
Uniprot Name
3SOKA_HEMHA
Alphafold ID
P0DQH2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQH2
Sequence
LECYQKSKVVTCQPEQKFCYSDTTMFFPNHPVYLSGCTFSCTEEGNRRCCTTDKCNR
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Sequence Length
57
Mass (Da)
6630
Sequence Removed Signal Peptide
LECYQKSKVVTCQPEQKFCYSDTTMFFPNHPVYLSGCTFSCTEEGNRRCCTTDKCNR
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Disulfide Bond
3-19;12-37;41-49;50-55
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Hemachatus
Species: Hemachatus haemachatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    F7a/TF/F10/phospholipids complex Inhibition constant
30.62 nM
 . . [1]
 Target Info    F7a/TF/phospholipids complex Inhibition constant
153.75 nM
 . . [1]
 Target Info    extrinsic tenase complex (ETC) IC50
116.49 nM
 . . [1]
 Target Info    intrinsic tenase complex IC50
4.05 μM
 . . [1]
 Target Info    prothrombinase complex IC50
17.66 μM
 . . [1]
References
Ref 1 Exactin: A specific inhibitor of Factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus. Sci Rep. 2016 Aug 25;6:32036. doi: 10.1038/srep32036.
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