Peptide Information

General Information of This Peptide
Peptide ID
BTDP005202
Peptide Name
Alpha-conotoxin-like Tx1.2
Symonym
Conotoxin Tx1.1
Species
Conus textile (Cloth-of-gold cone)
Uniprot Name
CA1Z_CONTE
Alphafold ID
P0DPL9
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DPL9
Sequence
MFTVFLLVVLATTVVSFTSGRSTFRGRNAAAKASGLVSLTDRRPQCCSHPACNVDHPEIC
R
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Sequence Length
61
Mass (Da)
6597
Signal Sequence
MFTVFLLVVLATTVVSFTSG
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Sequence Removed Signal Peptide
RSTFRGRNAAAKASGLVSLTDRRPQCCSHPACNVDHPEICR
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Disulfide Bond
46-52;47-60
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus textile
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    GABBR1 and/or GABBR2 Inhibition rate
8 %
1 μM
 . [1], [2]
References
Ref 1 Constrained de novo sequencing of conotoxins. J Proteome Res. 2012 Aug 3;11(8):4191-200. doi: 10.1021/pr300312h. Epub 2012 Jul 2.
Ref 2 Structure-Activity Studies of Cysteine-Rich -Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4692-6. doi: 10.1002/anie.201600297. Epub 2016 Mar 7.
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