Peptide Information

General Information of This Peptide
Peptide ID
BTDP004938
Peptide Name
Alpha-conotoxin LsIA
Species
Conus limpusi (Cone snail)
Uniprot Name
CA1A_CONLM
Alphafold ID
P0DL68
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DL68
Sequence
SGCCSNPACRVNNPNIC
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Sequence Length
17
Mass (Da)
1752
Sequence Removed Signal Peptide
SGCCSNPACRVNNPNIC
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Disulfide Bond
3-9;4-17
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus limpusi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7 IC50
0.3 - 10.1 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
10.3 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-alpha-5-beta-2 IC50
31.2 nM
 . . [1], [2]
References
Ref 1 Isolation and characterization of -conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem Pharmacol. 2013 Sep 15;86(6):791-9. doi: 10.1016/j.bcp.2013.07.016. Epub 2013 Aug 4.
Ref 2 Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of -conotoxin AusIA. Sci Rep. 2021 Nov 9;11(1):21928. doi: 10.1038/s41598-021-01277-4.
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