Peptide Information

General Information of This Peptide
Peptide ID
BTDP004876
Peptide Name
Conantokin Rl-C
Symonym
Con Rl-C; ConRl-C
Species
Conus rolani (Cone snail)
Uniprot Name
CKR1C_CONRO
Alphafold ID
P0DKZ1
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DKZ1
Sequence
MQLYTYLYLLVPLVTFHLILGTGTLDHGDALTERRSADATALKPEPVLLQKSSARSTDDN
GKDTQMKRIFKKRRNKARGEEELSENAVEFARELAN
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Sequence Length
96
Mass (Da)
10864
Signal Sequence
MQLYTYLYLLVPLVTFHLILG
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Sequence Removed Signal Peptide
TGTLDHGDALTERRSADATALKPEPVLLQKSSARSTDDNGKDTQMKRIFKKRRNKARGEE
ELSENAVEFARELAN
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus rolani
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    NR2B IC50
1.4 μM
 . . [1]
 Target Info    NR2A IC50
2.9 μM
 . . [1]
References
Ref 1 Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry. 2012 Jun 12;51(23):4685-92. doi: 10.1021/bi300055n. Epub 2012 May 30.
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