Peptide Information

General Information of This Peptide
Peptide ID
BTDP004716
Peptide Name
Kunitz-type kappaPI-theraphotoxin-Hs1c
Symonym
Huwentoxin HW11c27; Kunitz-type serine protease inhibitor HWTX-XI-IS27
Species
Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Uniprot Name
VKT27_CYRSC
Alphafold ID
P0DJ82
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DJ82
Sequence
MGIARILSAVLFLSVLFVVTFPALLSADHHDGRIDTCRLPSDRGRCKASFECWYFNGRTC
AKFIYGGCGGNGNKFPTQEACMKRCAKA
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Sequence Length
88
Mass (Da)
9668
Signal Sequence
MGIARILSAVLFLSVLFVVTFPALLSA
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Sequence Removed Signal Peptide
DHHDGRIDTCRLPSDRGRCKASFECWYFNGRTCAKFIYGGCGGNGNKFPTQEACMKRCAK
A
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Disulfide Bond
37-85;46-68;60-81
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus schmidti
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
0.281 nM
 . . [1], [2]
 Target Info    plasma kallikrein Inhibition constant
337 nM
 . . [1], [2]
References
Ref 1 Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas. PLoS One. 2008;3(10):e3414. doi: 10.1371/journal.pone.0003414. Epub 2008 Oct 15.
Ref 2 Molecular cloning, bioinformatics analysis and functional characterization of HWTX-XI toxin superfamily from the spider Ornithoctonus huwena. Peptides. 2014 Apr;54:9-18. doi: 10.1016/j.peptides.2014.01.001. Epub 2014 Jan 10.
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