Peptide Information

General Information of This Peptide
Peptide ID
BTDP004715
Peptide Name
Kunitz-type U15-theraphotoxin-Hs1e
Symonym
Huwentoxin HW11c24; Kunitz-type serine protease inhibitor HWTX-XI-IS24
Species
Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Uniprot Name
VKT24_CYRSC
Alphafold ID
P0DJ81
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DJ81
Sequence
MGTARFLSAVLLLSVLLMVTFPALLSAEYHDGRVDICSLPSDSGDRLRFFEMWYFDGTTC
TKFVYGGYGGNDNRFPTEKACMKRCAKA
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Sequence Length
88
Mass (Da)
9832
Signal Sequence
MGTARFLSAVLLLSVLLMVTFPALLSA
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Sequence Removed Signal Peptide
EYHDGRVDICSLPSDSGDRLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAK
A
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Disulfide Bond
37-85;60-81
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus schmidti
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
9.61 nM
 . . [1], [2]
 Target Info    plasma kallikrein Inhibition constant
24.8 nM
 . . [1], [2]
References
Ref 1 Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas. PLoS One. 2008;3(10):e3414. doi: 10.1371/journal.pone.0003414. Epub 2008 Oct 15.
Ref 2 Molecular cloning, bioinformatics analysis and functional characterization of HWTX-XI toxin superfamily from the spider Ornithoctonus huwena. Peptides. 2014 Apr;54:9-18. doi: 10.1016/j.peptides.2014.01.001. Epub 2014 Jan 10.
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