Peptide Information

General Information of This Peptide
Peptide ID
BTDP004653
Peptide Name
Omega-conotoxin Bu8
Species
Conus bullatus (Bubble cone)
Uniprot Name
O168_CONBU
Alphafold ID
P0CY66
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5ZNU
Sequence
AEDSRGTQLHRALRKATKLSESTRCKRKGSSCRRTSYDCCTGSCRNGKCG
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Sequence Length
50
Mass (Da)
5511
Sequence Removed Signal Peptide
AEDSRGTQLHRALRKATKLSESTRCKRKGSSCRRTSYDCCTGSCRNGKCG
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Disulfide Bond
25-40;32-44;39-49
PDB ID
5ZNU
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus bullatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav1.1 Inhibition rate
2.82 %
10 μM
 . [1], [2]
 Target Info    Cav2.1 Inhibition rate
27.36 %
10 μM
 . [1], [2]
 Target Info    Cav2.2 IC50
89 nM
 . . [1], [2]
References
Ref 1 Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics. 2011 Jan 25;12:60. doi: 10.1186/1471-2164-12-60.
Ref 2 A novel -conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity. Acta Pharm Sin B. 2021 Sep;11(9):2685-2693. doi: 10.1016/j.apsb.2021.03.001. Epub 2021 Mar 18.
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