Peptide Information

General Information of This Peptide
Peptide ID
BTDP004592
Peptide Name
Potassium channel toxin alpha-KTx 29.3
Symonym
Neurotoxin LmKTx95; Neurotoxin-E
Species
Lychas mucronatus (Chinese swimming scorpion)
Uniprot Name
KA293_LYCMC
Alphafold ID
P0CI86
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0CI86
Sequence
MKSVCGVLIILVVLTTMLSISTFSTVGAEADCPISEAIKCVEKCNQKVEVCEPGVCKCSG
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Sequence Length
60
Mass (Da)
6267
Signal Sequence
MKSVCGVLIILVVLTTMLSISTFSTVGA
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Sequence Removed Signal Peptide
EADCPISEAIKCVEKCNQKVEVCEPGVCKCSG
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Disulfide Bond
32-51;40-56;44-58
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Lychas
Species: Lychas mucronatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition rate
13.2 %
1 μM
 . [1], [2]
 Target Info    Kv7.1 Inhibition rate
27.7 %
10 μM
 . [1], [2]
References
Ref 1 Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components. BMC Genomics. 2010 Jul 28;11:452. doi: 10.1186/1471-2164-11-452.
Ref 2 Structural and functional diversity of acidic scorpion potassium channel toxins. PLoS One. 2012;7(4):e35154. doi: 10.1371/journal.pone.0035154. Epub 2012 Apr 12.
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