Peptide Information

General Information of This Peptide
Peptide ID
BTDP004503
Peptide Name
Conantokin-Br
Symonym
Conantoxin-S1
Species
Conus sulcatus (Sulcate cone)
Uniprot Name
CKBR_CONSL
Alphafold ID
P0CG46
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0CG46
Sequence
MQLYTYLYLLVPLVTFHLILGTGTLDHGGALTERRSTDATALKPEPVLQKSAARSTDDNG
KDRLTQMKRILKKRGKNARGDEEYSKFIEREREAGRLDLSKFP
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Sequence Length
103
Mass (Da)
11708
Sequence Removed Signal Peptide
MQLYTYLYLLVPLVTFHLILGTGTLDHGGALTERRSTDATALKPEPVLQKSAARSTDDNG
KDRLTQMKRILKKRGKNARGDEEYSKFIEREREAGRLDLSKFP
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus sulcatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    NR2B IC50
0.14 μM
 . . [1], [2]
 Target Info    NR2D IC50
0.31 μM
 . . [1], [2]
 Target Info    NR2A IC50
0.68 μM
 . . [1], [2]
 Target Info    NR2C IC50
4.9 μM
 . . [1], [2]
References
Ref 1 Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry. 2009 May 19;48(19):4063-73. doi: 10.1021/bi802259a.
Ref 2 Hyperhydroxylation: a new strategy for neuronal targeting by venomous marine molluscs. Prog Mol Subcell Biol. 2006;43:83-103. doi: 10.1007/978-3-540-30880-5_4.
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