Peptide Information

General Information of This Peptide
Peptide ID
BTDP004480
Peptide Name
Mu-conotoxin SIIIB
Species
Conus striatus (Striated cone)
Uniprot Name
CM3B_CONST
Alphafold ID
P0CE77
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0CE77
Sequence
QNCCNGGCSSKWCKGHARCC
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Sequence Length
20
Mass (Da)
2145
Sequence Removed Signal Peptide
QNCCNGGCSSKWCKGHARCC
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Disulfide Bond
3-13;4-19;8-20
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 IC50
3 nM
 . . [1], [2]
 Target Info    Nav1.2 IC50
5 nM
 . . [1], [2]
References
Ref 1 Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J Biol Chem. 2008 Aug 1;283(31):21621-8. doi: 10.1074/jbc.M802852200. Epub 2008 Jun 3.
Ref 2 N- and C-terminal extensions of -conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers. 2012;98(2):161-5. doi: 10.1002/bip.22032. Epub 2012 Feb 10.
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