Peptide Information

General Information of This Peptide
Peptide ID
BTDP004366
Peptide Name
Mu-conotoxin SxIIIA
Species
Conus striolatus (Cone snail)
Uniprot Name
CM3A_CONSR
Alphafold ID
P0C8V2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C8V2
Sequence
RCCTGKKGSCSGRACKNLKCCA
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Sequence Length
22
Mass (Da)
2278
Sequence Removed Signal Peptide
RCCTGKKGSCSGRACKNLKCCA
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Disulfide Bond
2-15;3-20;10-21
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striolatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 IC50
7 nM
 . . [1], [2], [3]
 Target Info    Nav1.1 IC50
370 nM
 . . [1], [2], [3]
 Target Info    Nav1.6 IC50
570 nM
 . . [1], [2], [3]
 Target Info    Nav1.2 IC50
1 μM
 . . [1], [2], [3]
References
Ref 1 NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA. J Am Chem Soc. 2008 Oct 29;130(43):14280-6. doi: 10.1021/ja804303p. Epub 2008 Oct 3.
Ref 2 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.
Ref 3 - and -subunit composition of voltage-gated sodium channels investigated with -conotoxins and the recently discovered O-conotoxin GVIIJ. J Neurophysiol. 2015 Apr 1;113(7):2289-301. doi: 10.1152/jn.01004.2014. Epub 2015 Jan 28.
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