Peptide Information

General Information of This Peptide
Peptide ID
BTDP004351
Peptide Name
Alpha-conotoxin ArIA
Species
Conus arenatus (Sand-dusted cone)
Uniprot Name
CA1A_CONAE
Alphafold ID
P0C8R2
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0C8R2
Sequence
SDGRNVAAKAFHRIGRTIRDECCSNPACRVNNPHVCRRR
   Click to Show/Hide
Sequence Length
39
Mass (Da)
4437
Sequence Removed Signal Peptide
SDGRNVAAKAFHRIGRTIRDECCSNPACRVNNPHVCRRR
   Click to Show/Hide
Disulfide Bond
22-28;23-36
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus arenatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7 IC50
1.8 nM
 . . [1], [2]
 Target Info    nAChR alpha-7 IC50
6 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
18 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
60.1 nM
 . . [1], [2]
References
Ref 1 Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist. Biochemistry. 2007 Jun 5;46(22):6628-38. doi: 10.1021/bi7004202. Epub 2007 May 12.
Ref 2 Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. J Pharmacol Exp Ther. 2008 Nov;327(2):529-37. doi: 10.1124/jpet.108.142943. Epub 2008 Jul 29.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.