Peptide Information

General Information of This Peptide
Peptide ID
BTDP004083
Peptide Name
Alpha-conotoxin RVIIIA
Symonym
AlphaS-conotoxin RVIIIA
Species
Conus radiatus (Rayed cone)
Uniprot Name
CSA8A_CONRA
Alphafold ID
P0C1W3
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0C1W3
Sequence
MMSKMGAMFVLLLLFTLASSQQEGDVQARKTHPKREFQRILLRSGRKCNFDKCKGTGVYN
CGESCSCEGLHSCRCTYNIGSMKSGCACICTYY
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Sequence Length
93
Mass (Da)
10383
Signal Sequence
MMSKMGAMFVLLLLFTLASS
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Sequence Removed Signal Peptide
QQEGDVQARKTHPKREFQRILLRSGRKCNFDKCKGTGVYNCGESCSCEGLHSCRCTYNIG
SMKSGCACICTYY
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus radiatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-9-alpha-10 IC50
187 nM
 . . [1], [2], [3]
References
Ref 1 Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol Phylogenet Evol. 2010 Jul;56(1):1-12. doi: 10.1016/j.ympev.2010.03.029. Epub 2010 Apr 2.
Ref 2 Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors. Biochemistry. 2005 May 31;44(21):7897-902. doi: 10.1021/bi047274+.
Ref 3 S-conotoxin GVIIIB potently and selectively blocks 910 nicotinic acetylcholine receptors. Biochem Pharmacol. 2015 Aug 15;96(4):349-56. doi: 10.1016/j.bcp.2015.06.007. Epub 2015 Jun 11.
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