Peptide Information

General Information of This Peptide
Peptide ID
BTDP003900
Peptide Name
Short neurotoxin 1
Symonym
Neurotoxin alpha
Species
Naja pallida (Red spitting cobra)
Uniprot Name
3S11_NAJPA
Alphafold ID
P01426
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1IQ9
Sequence
LECHNQQSSQPPTTKTCPGETNCYKKVWRDHRGTIIERGCGCPTVKPGIKLNCCTTDKCN
N
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Sequence Length
61
Mass (Da)
6795
Sequence Removed Signal Peptide
LECHNQQSSQPPTTKTCPGETNCYKKVWRDHRGTIIERGCGCPTVKPGIKLNCCTTDKCN
N
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Disulfide Bond
3-23;17-40;42-53;54-59
PDB ID
1IQ9 , 1NEA , 3NDS
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja pallida
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Dissociation constant
0.07 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-7 Dissociation constant
3 μM
 . . [1], [2], [3]
References
Ref 1 Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. doi: 10.1074/jbc.272.39.24279.
Ref 2 Three-dimensional solution structure of a curaremimetic toxin from Naja nigricollis venom: a proton NMR and molecular modeling study. Biochemistry. 1992 Nov 24;31(46):11335-47. doi: 10.1021/bi00161a011.
Ref 3 Motions and structural variability within toxins: implication for their use as scaffolds for protein engineering. Protein Sci. 2003 Feb;12(2):266-77. doi: 10.1110/ps.0227703.
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