Peptide Information

General Information of This Peptide
Peptide ID
BTDP003868
Peptide Name
Long neurotoxin 2
Symonym
Neurotoxin B; Tx-NM4
Species
Naja melanoleuca (Forest cobra) (Black-lipped cobra)
Uniprot Name
3L22_NAJME
Alphafold ID
P01388
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P01388
Sequence
IRCFITPDVTSQICADGHVCYTKTWCDNFCASRGKRVDLGCAATCPTVKPGVNIKCCSTD
NCNPFPTRNRP
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Sequence Length
71
Mass (Da)
7772
Sequence Removed Signal Peptide
IRCFITPDVTSQICADGHVCYTKTWCDNFCASRGKRVDLGCAATCPTVKPGVNIKCCSTD
NCNPFPTRNRP
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Disulfide Bond
3-20;14-41;26-30;45-56;57-62
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja melanoleuca
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-gamma-delta Inhibition constant
2.17 nM
 . . [1], [2]
 Target Info    nAChR alpha-7 Inhibition constant
26.9 nM
 . . [1], [2]
 Target Info    nAChR alpha-1-beta-2-gamma-2 IC50
˜10 μM
 . . [1], [2]
 Target Info    nAChR alpha-1-beta-3-gamma-2 IC50
˜10 μM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2-gamma-2 IC50
˜10 μM
 . . [1], [2]
References
Ref 1 Snake venom toxins. The amino acid sequences of toxins b and d from Naja melanoleuca venom. J Biol Chem. 1972 May 10;247(9):2866-71.
Ref 2 Novel Three-Finger Neurotoxins from Naja melanoleuca Cobra Venom Interact with GABA(A) and Nicotinic Acetylcholine Receptors. Toxins (Basel). 2021 Feb 20;13(2):164. doi: 10.3390/toxins13020164.
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