Peptide Information

General Information of This Peptide
Peptide ID
BTDP003856
Peptide Name
Bradykinin-potentiating and C-type natriuretic peptides
Symonym
Angiotensin-converting enzyme inhibitor; BPP-CNP homolog
Species
Gloydius blomhoffii (Mamushi) (Agkistrodon halys blomhoffi)
Uniprot Name
BNP_GLOBL
Alphafold ID
P01021
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 4AA2
Sequence
MFVSRLAASGLLLLALMALSLDGKPVQQWSQGRPPGPPIPRLVVQQWSQGLPPGPPIPRL
VVQQWSQGLPPGPPIPPLVVQQWSQGLPPRPKIPPLVVQQWSQGLPPRPKIPPLVVQKWD
PPPVSPPLLLQPHESPAGGTTALREELSLGPEAASGPAAAGADGGRSGSKAPAALHRLSK
SKGASATSASASRPMRDLRTDGKQARQNWARMVNPDHHAVGGCCCGGGGGGARRLKGLVK
KGVAKGCFGLKLDRIGTMSGLGC
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Sequence Length
263
Mass (Da)
27339
Signal Sequence
MFVSRLAASGLLLLALMALSLDG
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Sequence Removed Signal Peptide
KPVQQWSQGRPPGPPIPRLVVQQWSQGLPPGPPIPRLVVQQWSQGLPPGPPIPPLVVQQW
SQGLPPRPKIPPLVVQQWSQGLPPRPKIPPLVVQKWDPPPVSPPLLLQPHESPAGGTTAL
REELSLGPEAASGPAAAGADGGRSGSKAPAALHRLSKSKGASATSASASRPMRDLRTDGK
QARQNWARMVNPDHHAVGGCCCGGGGGGARRLKGLVKKGVAKGCFGLKLDRIGTMSGLGC
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Disulfide Bond
247-263
PDB ID
4AA2 , 4APJ
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Gloydius
Species: Gloydius blomhoffii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    angiotensin-converting enzyme (ACE) Inhibition constant
30 nM
 . . [1- 9]
 Target Info    angiotensin-converting enzyme (ACE) IC50
1.1 μM
 . . [1- 9]
 Target Info    angiotensin-converting enzyme (ACE) IC50
7.1 μM
 . . [1- 9]
 Target Info    angiotensin-converting enzyme (ACE) IC50
15 μM
 . . [1- 9]
 Target Info    angiotensin-converting enzyme (ACE) IC50
46 μM
 . . [1- 9]
References
Ref 1 Bradykinin-potentiating peptides and C-type natriuretic peptides from snake venom. Immunopharmacology. 1999 Oct 15;44(1-2):129-35. doi: 10.1016/s0162-3109(99)00119-8.
Ref 2 Blomhotin: a novel peptide with smooth muscle contractile activity identified in the venom of Agkistrodon halys blomhoffii. Toxicon. 1999 Dec;37(12):1761-70. doi: 10.1016/s0041-0101(99)00117-8.
Ref 3 Structure of potentiator A, one of the five bradykinin potentiating peptides from the venom of Agkistrodon halys blomhoffii. Experientia. 1973 May 15;29(5):574-5. doi: 10.1007/BF01926673.
Ref 4 Bradykinin-potentiating peptides from the venom of Agkistrodon halys blomhoffi. Isolation of five bradykinin potentiators and the amino acid sequences of two of them, potentiators B and C. Biochemistry. 1971 Mar 16;10(6):972-80. doi: 10.1021/bi00782a007.
Ref 5 cDNA cloning of bradykinin-potentiating peptides-C-type natriuretic peptide precursor, and characterization of the novel peptide Leu3-blomhotin from the venom of Agkistrodon blomhoffi. Eur J Biochem. 2000 Jul;267(13):4075-80. doi: 10.1046/j.1432-1327.2000.01443.x.
Ref 6 Selective inhibition of the C-domain of angiotensin I converting enzyme by bradykinin potentiating peptides. Biochemistry. 2002 May 14;41(19):6065-71. doi: 10.1021/bi012121x.
Ref 7 Identification of novel bradykinin-potentiating peptides (BPPs) in the venom gland of a rattlesnake allowed the evaluation of the structure-function relationship of BPPs. Biochem Pharmacol. 2007 Nov 1;74(9):1350-60. doi: 10.1016/j.bcp.2007.07.014. Epub 2007 Jul 17.
Ref 8 Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila?melanogaster. FEBS J. 2012 Dec;279(24):4525-34. doi: 10.1111/febs.12038. Epub 2012 Nov 22.
Ref 9 Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides. Sci Rep. 2012;2:717. doi: 10.1038/srep00717. Epub 2012 Oct 9.
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