Peptide Information

General Information of This Peptide
Peptide ID
BTDP003844
Peptide Name
Acidic phospholipase A2
Symonym
Phosphatidylcholine 2-acylhydrolase
Species
Crotalus atrox (Western diamondback rattlesnake)
Uniprot Name
PA2A_CROAT
Alphafold ID
P00624
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1PP2
Sequence
MRTLWIVAVLLLGVEGSLVQFETLIMKIAGRSGLLWYSAYGCYCGWGGHGLPQDATDRCC
FVHDCCYGKATDCNPKTVSYTYSEENGEIICGGDDPCGTQICECDKAAAICFRDNIPSYD
NKYWLFPPKNCREEPEPC
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Sequence Length
138
Mass (Da)
15346
Signal Sequence
MRTLWIVAVLLLGVEG
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Sequence Removed Signal Peptide
SLVQFETLIMKIAGRSGLLWYSAYGCYCGWGGHGLPQDATDRCCFVHDCCYGKATDCNPK
TVSYTYSEENGEIICGGDDPCGTQICECDKAAAICFRDNIPSYDNKYWLFPPKNCREEPE
PC
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Disulfide Bond
42-131;44-60;59-111;65-138;66-104;73-97;91-102
PDB ID
1PP2
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Crotalus
Species: Crotalus atrox
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
References
Ref 1 Crotalus atrox phospholipase A2. Amino acid sequence and studies on the function of the NH2-terminal region. J Biol Chem. 1982 Mar 10;257(5):2155-61.
Ref 2 Exploring the venom proteome of the western diamondback rattlesnake, Crotalus atrox, via snake venomics and combinatorial peptide ligand library approaches. J Proteome Res. 2009 Jun;8(6):3055-67. doi: 10.1021/pr900249q.
Ref 3 The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox. J Biol Chem. 1981 Aug 25;256(16):8602-7.
Ref 4 The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center. J Biol Chem. 1985 Aug 15;260(17):9742-9.
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