Peptide Information

General Information of This Peptide
Peptide ID
BTDP003771
Peptide Name
Basic phospholipase A2 B
Symonym
BPLA(2); Phosphatidylcholine 2-acylhydrolase; bAhp
Species
Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
Uniprot Name
PA2BB_GLOHA
Alphafold ID
O42187
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1B4W
Sequence
MRALWIVAVLLLGVEGSLLQFRKMIKKMTGKEPVVSYAFYGCYCGSGGRGKPKDATDRCC
FVHDCCYEKLTGCDPKWDDYTYSWKNGTIVCGGDDPCKKEVCECDKAAAICFRDNLKTYK
KRYMTYPNILCSSKSEKC
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Sequence Length
138
Mass (Da)
15614
Signal Sequence
MRALWIVAVLLLGVEG
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Sequence Removed Signal Peptide
SLLQFRKMIKKMTGKEPVVSYAFYGCYCGSGGRGKPKDATDRCCFVHDCCYEKLTGCDPK
WDDYTYSWKNGTIVCGGDDPCKKEVCECDKAAAICFRDNLKTYKKRYMTYPNILCSSKSE
KC
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Disulfide Bond
42-131;44-60;59-111;65-138;66-104;73-97;91-102
PDB ID
1B4W , 1C1J , 1JIA , 4HG9
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Gloydius
Species: Gloydius halys
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    factor Xa (F10) IC50
90 nM
 . . [1- 5]
References
Ref 1 Cloning of the BPLA(2) Gene from Agkistrodon halys Pallas. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1996;28(6):579-582.
Ref 2 Diversity of cDNAs encoding phospholipase A2 from Agkistrodon halys pallas venom, and its expression in E. coli. Toxicon. 1998 Aug;36(8):1155-63. doi: 10.1016/s0041-0101(98)00013-0.
Ref 3 Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics. BMC Struct Biol. 2007 Dec 6;7:82. doi: 10.1186/1472-6807-7-82.
Ref 4 Structure of a basic phospholipase A2 from Agkistrodon halys Pallas at 2.13 A resolution. Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):510-21. doi: 10.1107/s0907444997013644.
Ref 5 Structure of basic phospholipase A2 from Agkistrodon halys Pallas: implications for its association, hemolytic and anticoagulant activities. Toxicon. 2000 Jul;38(7):901-16. doi: 10.1016/s0041-0101(99)00193-2.
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