Peptide Information

General Information of This Peptide
Peptide ID
BTDP003719
Peptide Name
Alpha-conotoxin TxIB
Species
Conus textile (Cloth-of-gold cone)
Uniprot Name
CA1B_CONTE
Alphafold ID
K4RNX9
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2LZ5
Sequence
FDGRNTSANNKATDLMALPVRGCCSDPPCRNKHPDLCGGRR
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Sequence Length
41
Mass (Da)
4445
Sequence Removed Signal Peptide
FDGRNTSANNKATDLMALPVRGCCSDPPCRNKHPDLCGGRR
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Disulfide Bond
23-29;24-37
PDB ID
2LZ5
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus textile
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
28.4 nM
 . . [1], [2], [3]
References
Ref 1 Characterization of a novel -conotoxin from conus textile that selectively targets 6/323 nicotinic acetylcholine receptors. J Biol Chem. 2013 Jan 11;288(2):894-902. doi: 10.1074/jbc.M112.427898. Epub 2012 Nov 26.
Ref 2 Species specificity of rat and human 7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists. Neuropharmacology. 2018 Sep 1;139:226-237. doi: 10.1016/j.neuropharm.2018.07.019. Epub 2018 Jul 17.
Ref 3 Effects of Cyclization on Activity and Stability of -Conotoxin TxIB. Mar Drugs. 2020 Mar 29;18(4):180. doi: 10.3390/md18040180.
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