Peptide Information

General Information of This Peptide
Peptide ID
BTDP003715
Peptide Name
Alpha-conotoxin GeXIVA
Symonym
Alpha-O-conotoxin GeXIVA; Conotoxin Ge14.1; Conotoxin GeXIVAWT
Species
Conus generalis (General cone)
Uniprot Name
CO1EA_CONGR
Alphafold ID
J7GY56
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: J7GY56
Sequence
MKLTCVLIITVLFLTACQLTTAVTYSRGEHKHRALMSTGTNYRLPKTCRSSGRYCRSPYD
RRRRYCRRITDACV
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Sequence Length
74
Mass (Da)
8621
Signal Sequence
MKLTCVLIITVLFLTA
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Sequence Removed Signal Peptide
CQLTTAVTYSRGEHKHRALMSTGTNYRLPKTCRSSGRYCRSPYDRRRRYCRRITDACV
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus generalis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-9-alpha-10 IC50
4.61 - 12 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-9-alpha-10 IC50
22.7 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-9-alpha-10 IC50
716 nM
 . . [1], [2], [3], [4]
References
Ref 1 Expression, renaturation and biological activity of recombinant conotoxin GeXIVAWT. Appl Microbiol Biotechnol. 2013 Feb;97(3):1223-30. doi: 10.1007/s00253-012-4287-6. Epub 2012 Jul 24.
Ref 2 Cloning, synthesis, and characterization of O-conotoxin GeXIVA, a potent 910 nicotinic acetylcholine receptor antagonist. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4026-35. doi: 10.1073/pnas.1503617112. Epub 2015 Jul 13.
Ref 3 Anti-hypersensitive effect of intramuscular administration of O-conotoxin GeXIVA[1,2] and GeXIVA[1,4] in rats of neuropathic pain. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Apr 3;66:112-119. doi: 10.1016/j.pnpbp.2015.12.005. Epub 2015 Dec 17.
Ref 4 Structure and Activity Studies of Disulfide-Deficient Analogues of O-Conotoxin GeXIVA. J Med Chem. 2020 Feb 27;63(4):1564-1575. doi: 10.1021/acs.jmedchem.9b01409. Epub 2020 Feb 7.
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