Peptide Information

General Information of This Peptide
Peptide ID
BTDP003661
Peptide Name
Thrombin-like enzyme AhV_TL-I
Symonym
SVTLE AhV_TL-I; EC 3.4.21.-
Species
Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
Uniprot Name
VSPI_GLOHA
Alphafold ID
I4CHP3
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 4E7N
Sequence
IIGGDECNINEHRFLVALYTSRSRTLFCGGTLINQEWVLTAAHCDRKNFRIKLGMHSKKV
PNEDEQTRVPKEKFFCLSSKNYTLWDKDIMLIRLDSPVKNSKHIAPFSLPSSPPSVGSVC
RIMGWGRISPTEGTYPDVPHCVNINLLEYEMCRAPYPEFELPATSRTLCAGILEGGKDTC
KGDSGGPLICNGQFQGIASWGDDPCAQPHKPAAYTKVFDHLDWIENIIAGNTDASCPP
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Sequence Length
238
Mass (Da)
26387
Sequence Removed Signal Peptide
IIGGDECNINEHRFLVALYTSRSRTLFCGGTLINQEWVLTAAHCDRKNFRIKLGMHSKKV
PNEDEQTRVPKEKFFCLSSKNYTLWDKDIMLIRLDSPVKNSKHIAPFSLPSSPPSVGSVC
RIMGWGRISPTEGTYPDVPHCVNINLLEYEMCRAPYPEFELPATSRTLCAGILEGGKDTC
KGDSGGPLICNGQFQGIASWGDDPCAQPHKPAAYTKVFDHLDWIENIIAGNTDASCPP
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Disulfide Bond
7-141;28-44;76-236;120-190;152-169;180-205
PDB ID
4E7N
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Gloydius
Species: Gloydius halys
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    thoracic aortic ring Effective concentration 50
147 nmol/L
 . . [1]
References
Ref 1 Crystal structure and activating effect on RyRs of AhV_TL-I, a glycosylated thrombin-like enzyme from Agkistrodon halys snake venom. Arch Toxicol. 2013 Mar;87(3):535-45. doi: 10.1007/s00204-012-0957-5. Epub 2012 Oct 11.
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