Peptide Information

General Information of This Peptide
Peptide ID
BTDP003625
Peptide Name
Basic phospholipase A2 homolog MitTx-beta
Symonym
svPLA2 homolog
Species
Micrurus tener tener (Texas coral snake)
Uniprot Name
PA2HB_MICTN
Alphafold ID
G9I930
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 4NTW
Sequence
MDKMNPAHLLVLAAVCVSLLGASSIPPQALNLNQFRLMIKCTNDRVWADFVDYGCYCVAR
DSNTPVDDLDRCCQAQKQCYDEAVKVHGCKPLVMFYSFECRYLASDLDCSGNNTKCRNFV
CNCDRTATLCILTATYNRNNHKIDPSRCQ
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Sequence Length
149
Mass (Da)
16793
Signal Sequence
MDKMNPAHLLVLAAVCVSLLGASS
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Sequence Removed Signal Peptide
IPPQALNLNQFRLMIKCTNDRVWADFVDYGCYCVARDSNTPVDDLDRCCQAQKQCYDEAV
KVHGCKPLVMFYSFECRYLASDLDCSGNNTKCRNFVCNCDRTATLCILTATYNRNNHKID
PSRCQ
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Disulfide Bond
41-100;55-148;57-73;72-130;79-123;89-116;109-121
PDB ID
4NTW , 4NTX , 4NTY
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Micrurus
Species: Micrurus tener
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    acid-sensing ion channel (ASIC) Effective concentration 50
9.4 nM
 . . [1], [2]
 Target Info    acid-sensing ion channel (ASIC) Effective concentration 50
23 nM
 . . [1], [2]
 Target Info    ASIC3 Effective concentration 50
830 nM
 . . [1], [2]
References
Ref 1 A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16;479(7373):410-4. doi: 10.1038/nature10607.
Ref 2 X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel. Cell. 2014 Feb 13;156(4):717-29. doi: 10.1016/j.cell.2014.01.011. Epub 2014 Feb 6.
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