Peptide Information

General Information of This Peptide
Peptide ID
BTDP003613
Peptide Name
Dipetalodipin
Symonym
Salivary lipocalin
Species
Dipetalogaster maximus (Blood-sucking bug)
Uniprot Name
DPTL_DIPMA
Alphafold ID
G3CJS0
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: G3CJS0
Sequence
MKTIIAAIFLGILMHAFAKECTLMAAASNFNSDKYFDVPHVYVTHSKNGPKEKVCREYNT
TKNSDKTTSTTVVTLKTGGTQSIVLSCNNSPKSGVKGQYFMDCQVPGGTGGINIQLESSI
IATDNKNYALVHFCPITGRGVTEDIVVLQTNKDNVDPGVTSAIKNYGWSLENWKSRKDAG
CQ
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Sequence Length
182
Mass (Da)
19763
Signal Sequence
MKTIIAAIFLGILMHAFA
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Sequence Removed Signal Peptide
KECTLMAAASNFNSDKYFDVPHVYVTHSKNGPKEKVCREYNTTKNSDKTTSTTVVTLKTG
GTQSIVLSCNNSPKSGVKGQYFMDCQVPGGTGGINIQLESSIIATDNKNYALVHFCPITG
RGVTEDIVVLQTNKDNVDPGVTSAIKNYGWSLENWKSRKDAGCQ
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Disulfide Bond
21-134;55-181;87-103
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Hemiptera
Family: Reduviidae
Genus: Dipetalogaster
Species: Dipetalogaster maximus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    collagen IC50
30 nM
 . . [1], [2], [3]
References
Ref 1 Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2alpha, and 15(S)-HETE. J Biol Chem. 2010 Dec 10;285(50):39001-12. doi: 10.1074/jbc.M110.152835. Epub 2010 Oct 2.
Ref 2 Insight into the salivary transcriptome and proteome of Dipetalogaster maxima. J Proteome Res. 2011 Feb 4;10(2):669-79. doi: 10.1021/pr100866h. Epub 2011 Jan 4.
Ref 3 Salivary Thromboxane A2-Binding Proteins from Triatomine Vectors of Chagas Disease Inhibit Platelet-Mediated Neutrophil Extracellular Traps (NETs) Formation and Arterial Thrombosis. PLoS Negl Trop Dis. 2015 Jun 25;9(6):e0003869. doi: 10.1371/journal.pntd.0003869. eCollection 2015.
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