Peptide Information

General Information of This Peptide
Peptide ID
BTDP003585
Peptide Name
Tablysin 15
Symonym
Disintegrin
Species
Tabanus yao (Horsefly)
Uniprot Name
LYSF_TABYA
Alphafold ID
F8QQG5
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 3U3L
Sequence
MTSIPVSSFLLAALVLQYATSDAVNYCRLPCRGDNYHVGCGEPAYAQECGQSPRTRELLK
EHRNEILSKINDVRDHVAKGSWGLPVAARMKVVVWDAELAGLAKRHTKGCVGETHACRNT
ERFWLPGQLNFKYSGDKLPRIKELIDDAVKKGHLQKHNITREIIGNYRENGPNGDVKELA
LAISDRVTAVGCGLTTWQDGAKARALLTCNFSSQNTRGRPVYKIGNSPGEKCIEKDETYK
NLCPATEPIDPNKSN
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Sequence Length
255
Mass (Da)
28220
Signal Sequence
MTSIPVSSFLLAALVLQYATSDA
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Sequence Removed Signal Peptide
VNYCRLPCRGDNYHVGCGEPAYAQECGQSPRTRELLKEHRNEILSKINDVRDHVAKGSWG
LPVAARMKVVVWDAELAGLAKRHTKGCVGETHACRNTERFWLPGQLNFKYSGDKLPRIKE
LIDDAVKKGHLQKHNITREIIGNYRENGPNGDVKELALAISDRVTAVGCGLTTWQDGAKA
RALLTCNFSSQNTRGRPVYKIGNSPGEKCIEKDETYKNLCPATEPIDPNKSN
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Disulfide Bond
27-40;31-117;49-110;192-209;232-243
PDB ID
3U3L , 3U3N , 3U3U
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Tabanidae
Genus: Tabanus
Species: Tabanus yao
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    fibronectin IC50
1 μM
 . . [1], [2]
 Target Info    vitronectin IC50
1 nM
 . . [1], [2]
References
Ref 1 A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets IIb3 or V3 and inhibits platelet aggregation and angiogenesis. Thromb Haemost. 2011 Jun;105(6):1032-45. doi: 10.1160/TH11-01-0029. Epub 2011 Apr 7.
Ref 2 Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J Biol Chem. 2012 Mar 30;287(14):10967-76. doi: 10.1074/jbc.M112.340471. Epub 2012 Feb 6.
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