Peptide Information

General Information of This Peptide
Peptide ID
BTDP003555
Peptide Name
Alpha-conotoxin Lt28.1
Symonym
Conotoxin Lt15.2; Conotoxin Lt28.1
Species
Conus litteratus (Lettered cone)
Uniprot Name
CDS1_CONLT
Alphafold ID
F6JWU7
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: F6JWU7
Sequence
MPKLEMMLLVLLILPLCYIDAVGPPPPWNMEDEIIEHWQKLHCHEISDLTPWILCSPEPL
CGGKGCCAQEVCDCSGPACTCPPCL
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Sequence Length
85
Mass (Da)
9391
Signal Sequence
MPKLEMMLLVLLILPLCYIDA
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Sequence Removed Signal Peptide
VGPPPPWNMEDEIIEHWQKLHCHEISDLTPWILCSPEPLCGGKGCCAQEVCDCSGPACTC
PPCL
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Disulfide Bond
43;55;61-74;66-84;67-79;72-81
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus litteratus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-4-beta-2 Inhibition rate
18 %
10 μM
 . [1]
 Target Info    nAChR alpha-3-beta-2 Inhibition rate
19.4 %
10 μM
 . [1]
 Target Info    nAChR alpha-9-alpha-10 IC50
3 μM
 . . [1]
References
Ref 1 Cloning, expression and functional characterization of a D-superfamily conotoxin Lt28.1 with previously undescribed cysteine pattern. Peptides. 2017 Aug;94:64-70. doi: 10.1016/j.peptides.2017.06.008. Epub 2017 Jun 27.
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