Peptide Information

General Information of This Peptide
Peptide ID
BTDP003475
Peptide Name
Kappa-thalatoxin-Tas2a
Symonym
Kappa1.3-thalatoxin-Ta1a; Potassium channel peptide toxin ta-k
Species
Thalassianthus aster (Fuzzy-tipped anemone)
Uniprot Name
K1A_THAAS
Alphafold ID
E2S066
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: E2S066
Sequence
MKFQMIAAVLLIAFCLSVVVTARMELQDDEEMKNGSFQKRRTCIDTIPKSRCTAFQCKHS
MKYRLSFCRKTCGTC
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Sequence Length
75
Mass (Da)
8649
Signal Sequence
MKFQMIAAVLLIAFCLSVVVTA
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Sequence Removed Signal Peptide
RMELQDDEEMKNGSFQKRRTCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Disulfide Bond
43-75;52-68;57-72
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Thalassianthidae
Genus: Thalassianthus
Species: Thalassianthus aster
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
3.4 nM
 . . [1], [2]
References
Ref 1 Screening and cDNA cloning of Kv1 potassium channel toxins in sea anemones. Mar Drugs. 2010 Dec 2;8(12):2893-905. doi: 10.3390/md8122893.
Ref 2 Identification of novel Kv1.3 targeting venom peptides by a single round of autocrine-based selection. Biochem Biophys Res Commun. 2019 Feb 19;509(4):954-959. doi: 10.1016/j.bbrc.2019.01.014. Epub 2019 Jan 14.
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