Peptide Information

General Information of This Peptide
Peptide ID
BTDP003436
Peptide Name
Alpha-conotoxin Vt1.27
Species
Conus planorbis (Planorbis cone)
Uniprot Name
CA127_CONPO
Alphafold ID
D9IWN6
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: D9IWN6
Sequence
MGMRMMFTVFLLVVLATTVVSFTLDRASDGASAAADLVARGIRGNCCMFHTCPIDYSRFN
CP
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Sequence Length
62
Mass (Da)
6753
Signal Sequence
MGMRMMFTVFLLVVLATTVVS
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Sequence Removed Signal Peptide
FTLDRASDGASAAADLVARGIRGNCCMFHTCPIDYSRFNCP
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Disulfide Bond
46-52;47-61
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus planorbis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav2.2 IC50
398 nM
 . . [1]
 Target Info    nAChR alpha-3-beta-2 IC50
1.16 μM
 . . [1]
References
Ref 1 A 4/8 Subtype -Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect. Front Pharmacol. 2022 Apr 29;13:881732. doi: 10.3389/fphar.2022.881732. eCollection 2022.
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