Peptide Information

General Information of This Peptide
Peptide ID
BTDP003363
Peptide Name
Alpha-conotoxin EIIA
Species
Conus ermineus (Agate cone) (Chelyconus ermineus)
Uniprot Name
CA12A_CONER
Alphafold ID
D4HRK4
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: D4HRK4
Sequence
MFIVFLLVVLATTVGSFTLDRVLEGRNAAAIDNALDQRDPKRQTPGCCWNPACVKNRCGR
R
   Click to Show/Hide
Sequence Length
61
Mass (Da)
6779
Signal Sequence
MFIVFLLVVLATTVGS
   Click to Show/Hide
Sequence Removed Signal Peptide
FTLDRVLEGRNAAAIDNALDQRDPKRQTPGCCWNPACVKNRCGRR
   Click to Show/Hide
Disulfide Bond
47-53;48-58
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus ermineus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Inhibition constant
0.46 nM
 .
Two-site model
 [1], [2], [3]
 Target Info    nAChR Inhibition constant
105 nM
 .
Two-site model
 [1], [2], [3]
References
Ref 1 Evolution of Conus peptide genes: duplication and positive selection in the A-superfamily. J Mol Evol. 2010 Feb;70(2):190-202. doi: 10.1007/s00239-010-9321-7. Epub 2010 Feb 9.
Ref 2 Identification and functional characterization of a novel -conotoxin (EIIA) from Conus ermineus. Anal Bioanal Chem. 2013 Jun;405(15):5341-51. doi: 10.1007/s00216-013-6926-x. Epub 2013 Apr 14.
Ref 3 Discovery and characterization of EII(B,) a new -conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon. 2017 May;130:1-10. doi: 10.1016/j.toxicon.2017.02.023. Epub 2017 Feb 24.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.