Peptide Information

General Information of This Peptide
Peptide ID
BTDP003051
Peptide Name
Mu-theraphotoxin-Hhn2b 1
Symonym
Hainantoxin-I; Peptide F5-19.03
Species
Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Uniprot Name
H1A01_CYRHA
Alphafold ID
D2Y1X6
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1NIX
Sequence
MKASMFLALAGLVLLFVVCYASESEEKEFPRELISKIFAVDDFKGEERECKGFGKSCVPG
KNECCSGYACNSRDKWCKVLLGK
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Sequence Length
83
Mass (Da)
9240
Signal Sequence
MKASMFLALAGLVLLFVVCYA
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Sequence Removed Signal Peptide
SESEEKEFPRELISKIFAVDDFKGEERECKGFGKSCVPGKNECCSGYACNSRDKWCKVLL
GK
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Disulfide Bond
50-65;57-70;64-77
PDB ID
1NIX , 2MQF , 2MXO
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Haplopelma
Species: Haplopelma hainanum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    para/tipE IC50
4.3 μM
 . . [1], [2], [3], [4]
 Target Info    Nav1.2 IC50
68 μM
 . . [1], [2], [3], [4]
References
Ref 1 Molecular diversification of peptide toxins from the tarantula Haplopelma hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic, and genomic analyses. J Proteome Res. 2010 May 7;9(5):2550-64. doi: 10.1021/pr1000016.
Ref 2 Purification and characterization of Hainantoxin-V, a tetrodotoxin-sensitive sodium channel inhibitor from the venom of the spider Selenocosmia hainana. Toxicon. 2003 May;41(6):643-50. doi: 10.1016/s0041-0101(02)00280-5.
Ref 3 Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. FEBS Lett. 2003 Dec 18;555(3):616-22. doi: 10.1016/s0014-5793(03)01303-6.
Ref 4 Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7. Mol Pharmacol. 2015 Dec;88(6):1002-10. doi: 10.1124/mol.115.100784. Epub 2015 Oct 1.
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