Peptide Information

General Information of This Peptide
Peptide ID
BTDP002908
Peptide Name
Mu-conotoxin BuIIIB
Symonym
Conotoxin Bu16
Species
Conus bullatus (Bubble cone)
Uniprot Name
CM3B_CONBU
Alphafold ID
C1J5M6
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2LO9
Sequence
MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDISSEQNPLLEKRVGERCCKNG
KRGCGRWCRDHSRCCGRR
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Sequence Length
78
Mass (Da)
8877
Signal Sequence
MMSKLGVLLTICLLLFPLFALP
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Sequence Removed Signal Peptide
QDGDQPADRPAERMQDDISSEQNPLLEKRVGERCCKNGKRGCGRWCRDHSRCCGRR
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Disulfide Bond
56-68;57-74;64-75
PDB ID
2LO9 , 2LOC
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus bullatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Dissociation constant
0.34 - 3.6 nM
 . . [1- 5]
 Target Info    Nav1.2 Dissociation constant
13 nM
 . . [1- 5]
 Target Info    Nav1.3 Dissociation constant
200 nM
 . . [1- 5]
 Target Info    Nav1.1 Dissociation constant
360 nM
 . . [1- 5]
 Target Info    Nav1.6 IC50
>30 μM
 . . [1- 5]
 Target Info    Nav1.6 IC50
1.8 μM
 . . [1- 5]
 Target Info    Nav1.5 IC50
9 μM
 . . [1- 5]
References
Ref 1 Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan;53(1):90-8. doi: 10.1016/j.toxicon.2008.10.017. Epub 2008 Nov 20.
Ref 2 Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics. 2011 Jan 25;12:60. doi: 10.1186/1471-2164-12-60.
Ref 3 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.
Ref 4 - and -subunit composition of voltage-gated sodium channels investigated with -conotoxins and the recently discovered O-conotoxin GVIIJ. J Neurophysiol. 2015 Apr 1;113(7):2289-301. doi: 10.1152/jn.01004.2014. Epub 2015 Jan 28.
Ref 5 Mammalian neuronal sodium channel blocker -conotoxin BuIIIB has a structured N-terminus that influences potency. ACS Chem Biol. 2013;8(6):1344-51. doi: 10.1021/cb300674x. Epub 2013 Apr 16.
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