Peptide Information

General Information of This Peptide
Peptide ID
BTDP002652
Peptide Name
Pi-stichotoxin-Hcr5c
Symonym
APETx-like peptide; Pi-AnmTX Hcr 1b-3
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
BDS5C_HETCR
Alphafold ID
C0HL53
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: C0HL53
Sequence
GTPCKCHGYIGVYWFMLAGCPDGYGYNLSCPYFLGICCVKK
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Sequence Length
41
Mass (Da)
4529
Sequence Removed Signal Peptide
GTPCKCHGYIGVYWFMLAGCPDGYGYNLSCPYFLGICCVKK
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Disulfide Bond
4-37;6-30;20-38
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    acid-sensing ion channel (ASIC) IC50
4.95 μM
 . . [1], [2]
 Target Info    ASIC3 IC50
17 μM
 . . [1], [2]
References
Ref 1 New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels. Peptides. 2018 Jun;104:41-49. doi: 10.1016/j.peptides.2018.04.013. Epub 2018 Apr 22.
Ref 2 APETx-Like Peptides from the Sea Anemone Heteractis crispa, Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels. Toxins (Basel). 2020 Apr 20;12(4):266. doi: 10.3390/toxins12040266.
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