Peptide Information

General Information of This Peptide
Peptide ID
BTDP002627
Peptide Name
Alpha-conotoxin EIIB
Symonym
E1.2
Species
Conus ermineus (Agate cone) (Chelyconus ermineus)
Uniprot Name
CA2B_CONER
Alphafold ID
C0HKF6
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: C0HKF6
Sequence
MGMRMMFIVFLLVVLATTVVSFTLDHVLGLASEGRNAKAIDNALDQRDPKRQTPGCCWHP
ACGKNRCGRR
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Sequence Length
70
Mass (Da)
7775
Signal Sequence
MGMRMMFIVFLLVVLATTVVS
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Sequence Removed Signal Peptide
FTLDHVLGLASEGRNAKAIDNALDQRDPKRQTPGCCWHPACGKNRCGRR
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Disulfide Bond
56-62;57-67
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus ermineus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Inhibition constant
0.7 nM
 . . [1], [2]
 Target Info    [125I]-Bgtx from the Torpedo receptor Inhibition constant
2.2 nM
 . . [1], [2]
References
Ref 1 Conotoxin Diversity in Chelyconus ermineus (Born, 1778) and the Convergent Origin of Piscivory in the Atlantic and Indo-Pacific Cones. Genome Biol Evol. 2018 Oct 1;10(10):2643-2662. doi: 10.1093/gbe/evy150.
Ref 2 Discovery and characterization of EII(B,) a new -conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon. 2017 May;130:1-10. doi: 10.1016/j.toxicon.2017.02.023. Epub 2017 Feb 24.
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