Peptide Information

General Information of This Peptide
Peptide ID
BTDP002568
Peptide Name
TauPI-stichotoxin-Hcr2d
Symonym
Analgesic polypeptide HC3
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
VKT2D_HETCR
Alphafold ID
C0HJF3
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: C0HJF3
Sequence
GSICLEPKVVGPCTAYFPRFYFNSETGKCTPFIYGGCEGNGNNFETLRACRGICRA
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Sequence Length
56
Mass (Da)
6117
Sequence Removed Signal Peptide
GSICLEPKVVGPCTAYFPRFYFNSETGKCTPFIYGGCEGNGNNFETLRACRGICRA
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Disulfide Bond
4-54;13-37;29-50
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
0.5 μM
 . . [1], [2], [3], [4]
 Target Info    chymotrypsin Inhibition constant
7 μM
 . . [1], [2], [3], [4]
References
Ref 1 [New polypeptide components from the Heteractis crispa sea anemone with analgesic activity]. Bioorg Khim. 2009 Nov-Dec;35(6):789-98. doi: 10.1134/s1068162009060065.
Ref 2 Modulation of TRPV1-dependent contractility of normal and diabetic bladder smooth muscle by analgesic toxins from sea anemone Heteractis crispa. Life Sci. 2012 Nov 2;91(19-20):912-20. doi: 10.1016/j.lfs.2012.09.001. Epub 2012 Sep 12.
Ref 3 Polypeptide modulators of TRPV1 produce analgesia without hyperthermia. Mar Drugs. 2013 Dec 16;11(12):5100-15. doi: 10.3390/md11125100.
Ref 4 Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of Osteo- and Rheumatoid Arthritis. Mar Drugs. 2021 Jan 17;19(1):39. doi: 10.3390/md19010039.
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