Peptide Information

General Information of This Peptide
Peptide ID
BTDP002537
Peptide Name
Kunitz-type serine protease inhibitor TCI
Symonym
Trypsin and chymotrypsin bi-functional serine protease inhibitor
Species
Ophiophagus hannah (King cobra) (Naja hannah)
Uniprot Name
VKTCT_OPHHA
Alphafold ID
B6RLX2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: B6RLX2
Sequence
MSSGRLLLLLGLLTLWAELTPVSGLGRPKFCELPAVSGFCKAYIPSFYYNPDASACQKFI
YGGCGGNANKFKTIEECHRTCVG
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Sequence Length
83
Mass (Da)
8983
Signal Sequence
MSSGGLLLLLGLLTLWEALTPVSG
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Sequence Removed Signal Peptide
LGRPKFCELPAVSGFCKAYIPSFYYNPDASACQKFIYGGCGGNANKFKTIEECHRTCVG
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Disulfide Bond
31-81;40-64;56-77
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Ophiophagus
Species: Ophiophagus hannah
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    chymotrypsin Inhibition constant
84.6 nM
 . . [1], [2]
 Target Info    trypsin Inhibition constant
391 nM
 . . [1], [2]
References
Ref 1 Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom. Peptides. 2008 Oct;29(10):1692-9. doi: 10.1016/j.peptides.2008.05.025. Epub 2008 Jun 5.
Ref 2 The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20651-6. doi: 10.1073/pnas.1314702110. Epub 2013 Dec 2.
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