Peptide Information

General Information of This Peptide
Peptide ID
BTDP001850
Peptide Name
Alpha-conotoxin-like Pu1.2
Species
Conus pulicarius (Flea-bitten cone)
Uniprot Name
CA12_CONPL
Alphafold ID
A1X8D8
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: A1X8D8
Sequence
LDGRNAAADFETSDLLAMTIRGGCCSYPPCIANNPLCGGKR
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Sequence Length
41
Mass (Da)
4273
Sequence Removed Signal Peptide
LDGRNAAADFETSDLLAMTIRGGCCSYPPCIANNPLCGGKR
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Disulfide Bond
24-30;25-37
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus pulicarius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7 Inhibition rate .
3 μM
 . [1], [2]
 Target Info    nAChR alpha-9-alpha-10 Inhibition rate .
3 μM
 . [1], [2]
 Target Info    GABBR1 and/or GABBR2 Inhibition rate
27 %
1 μM
 . [1], [2]
References
Ref 1 From the identification of gene organization of alpha conotoxins to the cloning of novel toxins. Toxicon. 2007 Jun 15;49(8):1135-49. doi: 10.1016/j.toxicon.2007.02.011. Epub 2007 Mar 1.
Ref 2 Structure-Activity Studies of Cysteine-Rich -Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4692-6. doi: 10.1002/anie.201600297. Epub 2016 Mar 7.
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