Peptide Information

General Information of This Peptide
Peptide ID
BTDP001795
Peptide Name
Actinia tenebrosa protease inhibitors
Symonym
Carboxypeptidase inhibitor SmCI-like
Species
Actinia tenebrosa (Australian red waratah sea anemone)
Uniprot Name
ATPI1_ACTTE
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
MARTASTILFLLCLVLITGYTMARQEHCNLPLEKGKCGGRFERFYYNSHKGKCESFFYGG
CSGNDNNFENEEECDKACGAFMTMADANSFCNLPAVVGRCKGYFPRYFYNTEAGKCQRFI
YGGCGGNRNNFETVXDCRATCHPREKRALADMTMADANSFCQLPAVVGRCRGRFPRYYYN
TEAGKCQRFIYGGCXGNRNNFETVEDCRATCHPREKRALADMTMADANSFCQLPAVVGKC
RGYFPRYYYNTEAGKCQQFIYGGCGGNRNNFETVEDCRATCHSHA
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Sequence Length
285
Mass (Da)
32113
Signal Sequence
MARTASTILFLLCLVLITGYTMA
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Sequence Removed Signal Peptide
RQEHCNLPLEKGKCGGRFERFYYNSHKGKCESFFYGGCSGNDNNFENEEECDKACGAFMT
MADANSFCNLPAVVGRCKGYFPRYFYNTEAGKCQRFIYGGCGGNRNNFETVXDCRATCHP
REKRALADMTMADANSFCQLPAVVGRCRGRFPRYYYNTEAGKCQRFIYGGCXGNRNNFET
VEDCRATCHPREKRALADMTMADANSFCQLPAVVGKCRGYFPRYYYNTEAGKCQQFIYGG
CGGNRNNFETVEDCRATCHSHA
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Disulfide Bond
28-78;37-61;53-74;91-141;100-124;116-137;161-211;170-194;186-207;231-281;240-264;256-277
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Actinia
Species: Actinia tenebrosa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
0.05 nM
 . . [1], [2]
 Target Info    trypsin Inhibition constant
0.08 nM
 . . [1], [2]
 Target Info    chymotrypsin Inhibition constant
2.9 nM
 . . [1], [2]
 Target Info    chymotrypsin Inhibition constant
7.4 nM
 . . [1], [2]
References
Ref 1 The draft genome of Actinia tenebrosa reveals insights into toxin evolution. Ecol Evol. 2019 Sep 18;9(19):11314-11328. doi: 10.1002/ece3.5633. eCollection 2019 Oct.
Ref 2 A Versatile and Robust Serine Protease Inhibitor Scaffold from Actinia tenebrosa. Mar Drugs. 2019 Dec 12;17(12):701. doi: 10.3390/md17120701.
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