Peptide Information

General Information of This Peptide
Peptide ID
BTDP001794
Peptide Name
Cyclotide trypsin inhibitor TopI1
Species
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Uniprot Name
CYCTI_TITOB
Alphafold ID
A0A6P3CW73
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6MRQ
Sequence
MKFIIVLLLLTALTLTSIPVIEGILKRCKTYDDCKDVCKARKGKCEFGICKCMIKSGK
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Sequence Length
58
Mass (Da)
6482
Signal Sequence
MKFIIVLLLLTALTLTSIPVIEG
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Sequence Removed Signal Peptide
ILKRCKTYDDCKDVCKARKGKCEFGICKCMIKSGK
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Disulfide Bond
28-45;34-50;38-52
PDB ID
6MRQ
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Dissociation constant
˜0.5 nM
 . . [1]
References
Ref 1 Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides. J Med Chem. 2020 Sep 10;63(17):9500-9511. doi: 10.1021/acs.jmedchem.0c00686. Epub 2020 Aug 12.
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