Peptide Information

General Information of This Peptide
Peptide ID
BTDP001754
Peptide Name
PI-stichotoxin-Hcr2i
Symonym
Kunitz-peptide HCIQ2c1
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
VKT2I_HETCR
Alphafold ID
A0A6B7FBD3
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: A0A6B7FBD3
Sequence
MKGTFLICLILIAGFYFRSIQGFYFKRIQGNICSEPKKVGRCRGSFPRFYFDSETGKCTP
FIYGGCGGNGNNFETLHACRAICRA
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Sequence Length
85
Mass (Da)
9552
Signal Sequence
MKGTFLICLILIAGFYFRSIQG
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Sequence Removed Signal Peptide
FYFKRIQGNICSEPKKVGRCRGSFPRFYFDSETGKCTPFIYGGCGGNGNNFETLHACRAI
CRA
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Disulfide Bond
33-83;42-66;58-79
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
52 nM
 . . [1], [2]
References
Ref 1 A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine. Sci Rep. 2020 Mar 6;10(1):4205. doi: 10.1038/s41598-020-61034-x.
Ref 2 Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation. Int J Mol Sci. 2022 May 4;23(9):5115. doi: 10.3390/ijms23095115.
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