Peptide Information

General Information of This Peptide
Peptide ID
BTDP001738
Peptide Name
Alpha-conotoxin VnIB
Species
Conus ventricosus (Mediterranean cone)
Uniprot Name
CA1B_CONVE
Alphafold ID
A0A4P8XV20
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: A0A4P8XV20
Sequence
ASDGRNAAADDKASDPIALTVRGGCCSHPVCYTKNPNCGGRR
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Sequence Length
42
Mass (Da)
4306
Sequence Removed Signal Peptide
ASDGRNAAADDKASDPIALTVRGGCCSHPVCYTKNPNCGGRR
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Disulfide Bond
25-31;26-38
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus ventricosus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
5.3 nM
 . . [1]
 Target Info    nAChR alpha-6-beta-4 IC50
12 nM
 . . [1]
 Target Info    nAChR alpha-6-beta-4 IC50
12 nM
 . . [1]
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
18 nM
 . . [1]
 Target Info    nAChR alpha-3-beta-4 IC50
320 nM
 . . [1]
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
4 μM
 . . [1]
References
Ref 1 -Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of 64* nicotinic acetylcholine receptors. Neuropharmacology. 2019 Oct;157:107691. doi: 10.1016/j.neuropharm.2019.107691. Epub 2019 Jun 28.
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