Peptide Information

General Information of This Peptide
Peptide ID
BTDP001586
Peptide Name
Tau-scoloptoxin(04)-Sm1b
Symonym
Toxin RhTx2
Species
Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Uniprot Name
TX41A_SCOMU
Alphafold ID
A0A0N7CSQ4
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MVA
Sequence
MLKSFCILSVFMVLFLAKFPDLCSGEEISPLKIVVRNSEYLNNPCNGVTCPSGYRCSIVD
KQCIKKEK
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Sequence Length
68
Mass (Da)
7649
Signal Sequence
MLKSFCILSVFMVLFLAKFPDLCSG
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Sequence Removed Signal Peptide
EEISPLKIVVRNSEYLNNPCNGVTCPSGYRCSIVDKQCIKKEK
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Disulfide Bond
45-56;50-63
PDB ID
2MVA
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Chilopoda
Order: Scolopendromorpha
Family: Scolopendridae
Genus: Scolopendra
Species: Scolopendra mutilans
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    capsaicin receptor TRPV1 Effective concentration 50
470 - 521.5 nM
 . . [1], [2]
 Target Info    capsaicin receptor TRPV1 Effective concentration 50
38.35 μM
 . . [1], [2]
References
Ref 1 A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1. Nat Commun. 2015 Sep 30;6:8297. doi: 10.1038/ncomms9297.
Ref 2 A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel. Toxicon. 2020 Apr 30;178:41-49. doi: 10.1016/j.toxicon.2020.02.016. Epub 2020 Feb 22.
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