Peptide Information

General Information of This Peptide
Peptide ID
BTDP001579
Peptide Name
Elevenin-Vc1
Species
Conus victoriae (Queen Victoria cone)
Uniprot Name
CELE_CONVC
Alphafold ID
A0A0F7YZQ7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 8F04
Sequence
MAPSQKALLVLVLSMLLTASDSWARRIDCKVFVFAPICRGVAAKRGGDSLSVGGSAELDD
ALTDPFLRSEEPREWRELTRLSRVLQTFLSHPTGETEQHD
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Sequence Length
100
Mass (Da)
11056
Signal Sequence
MAPSQKALLVLVLSMLLTASDSRA
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Sequence Removed Signal Peptide
RRIDCKVFVFAPICRGVAAKRGGDSLSVGGSAELDDALTDPFLRSEEPREWRELTRLSRV
LQTFLSHPTGETEQHD
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Disulfide Bond
29-38
PDB ID
8F04
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus victoriae
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-epsilon-delta-epsilon Effect .
1 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-3-beta-2 Effect .
1 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-3-beta-4 Effect .
1 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-4-beta-2 Effect .
1 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-7 Effect .
1 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-9-alpha-10 Effect .
1 μM
 . [1], [2], [3]
References
Ref 1 Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. PLoS One. 2014 Feb 5;9(2):e87648. doi: 10.1371/journal.pone.0087648. eCollection 2014.
Ref 2 Hormone-like peptides in the venoms of marine cone snails. Gen Comp Endocrinol. 2017 Apr 1;244:11-18. doi: 10.1016/j.ygcen.2015.07.012. Epub 2015 Aug 22.
Ref 3 Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of -Conotoxins. Mar Drugs. 2023 Jan 25;21(2):81. doi: 10.3390/md21020081.
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