Peptide Information

General Information of This Peptide
Peptide ID
BTDP001017
Peptide Name
Potassium ion channel blocker P05 (N4R,L15R)
Symonym
Potassium ion channel blocker P05 (N4R,L15R)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
AVCNLKRCQLSCRSLGLLGKCIGDKCECVKH
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Mutant Sequence
AVCRLKRCQLSCRSRGLLGKCIGDKCECVKH
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Sequence Length
31
Mass(Da)
3458
Sequence Removed Signal Peptide
AVCRLKRCQLSCRSRGLLGKCIGDKCECVKH
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Disulfide Bond
3-21;8-26;12-28
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa2.3 Inhibition rate
10.7 %
100 nM
Blocker
 [1]
References
Ref 1 Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013 May 3;288(18):12544-53. doi: 10.1074/jbc.M112.433888. Epub 2013 Mar 19.
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